Protein Misfolding in Neurodegenerative Diseases (PDF)

By Neha Gogia MS PhD, Sandeep Kumar Singh Ph.D. in Biotechnology, Vidyadhara Devarunda Jaganath
Protein Misfolding in Neurodegenerative Diseases is a comprehensive review of proteome homeostasis in neurons, and in the brain. Beginning with an introduction on factors involved in the formation and aggregation of misfolded proteins, chapters then discuss the precise cellular and molecular mechanisms involved in these processes and their role in neurodegeneration and disease. Additional topics of focus include protein clearance mechanisms like protein quality control, disease-modifiers, molecular druggable targets, novel therapeutics, and emerging techniques that block or delay disease onset or progression. This volume is relevant for researchers working with neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, ALS, Creutzfeldt-Jakob disease, and more.

Discusses underlying cellular and molecular mechanisms altered in protein-associated neurodegenerative disorders
Describes methods for detection and analysis of protein aggregates
Features advancements in therapeutics and emerging techniques to treat these disorders
Covers implications in a variety of neurodegenerative diseases, including Alzheimer’s, Parkinson’s, ALS, Creutzfeldt-Jakob disease, Cystic fibrosis, Gaucher’s disease, and Polyglutamine diseases, including Huntington’s and other related proteinopathies

Product Details

Publisher ‏ : ‎ Academic Press
Publication date ‏ : ‎ April 3, 2025
Edition ‏ : ‎ 1st
Language ‏ : ‎ English
ISBN-10 ‏ : ‎ 0443187169
ISBN-13 ‏ : ‎ 978-0443187162